منابع مشابه
Environmental triggers and determinants of type 1 diabetes.
Type 1 diabetes is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects. A series of evidence supports a critical role of exogenous factors in the development of type 1 diabetes, such as 1) the fact that <10% of individuals with HLA-conferred...
متن کاملEnvironmental Factors before the Onset of Type 1 Diabetes Mellitus: A Case-Control Study
Objective: The role of environmental factors in the development of type1 diabetes mellitus (T1D) is inconclusive. This study aimed to investigate the associations between selected environmental factors and T1D. Materials and Methods: This group matched case-control study included diabetic and healthy subjects younger than 19 years old in 2017. Cases were diabetic subjects diagnosed before the ...
متن کاملNo Ljungan Virus RNA in Stool Samples From the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) Cohort Study
OBJECTIVE Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes. RESEARCH DESIGN AND METHODS A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian En...
متن کاملDietary proteins as environmental modifiers of type 1 diabetes mellitus.
Type 1 diabetes is an autoimmune disease in which the patient's immune system destroys the insulin-secreting beta-cells in the pancreatic islets of Langerhans. A majority of cases is thought to occur as a result of gene-environment interactions. The identity of the environmental factors remains unknown mainly because of the difficulty in linking past exposures with later disease development. Ov...
متن کاملIdentify the Genetic and Environmental Causes of Type 1 Diabetes
Recent Scientifi c Advances HLA Genes Contributing to the Risk of Type 1 Diabetes Contribution of INS to Type 1 Diabetes Susceptibility Other Genetic Factors Associated with Susceptibility to Type 1 Diabetes Exploration of Human Genomic Regions Associated with Type 1 Diabetes Susceptibility Genes and Genetic Concepts Discovered in Animal Models of Type 1 Diabetes Initiation of Studies To Identi...
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ژورنال
عنوان ژورنال: Journal of Paediatrics and Child Health
سال: 2001
ISSN: 1034-4810,1440-1754
DOI: 10.1046/j.1440-1754.2001.00658.x